Build Your System - Small Animal

Build your system – SMALL Animal

Mouse | Rat

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1. What is your standard study group size?

2. Are you experienced in handling and maintaining animals with vascular implants?

Yes No

3. What is the average blood sample volume that you collect? The Culex® system is capable of collecting 5uL to 1.0mL, depending on the species and vial type.

5uL-50uL 51uL-200uL 201uL-500uL

4. The most popular version of the Culex® system includes movement responsive caging called the Raturn. The Raturn makes it possible to connect multiple fluid or electrical lines directly to the same animal. For example, you can perform blood sampling, dosing, bile collection and bile salts infusion easily in the same system. It is an immense improvement over using a liquid swivel and makes your system extremely flexible.

I want to have the most flexible Culex® configuration so that I can get more out of my studies. I will only use the system for blood collection, please quote a swivel based system.

5. Whether you are using the Raturn or a liquid swivel, you can still decide how to connect to the animal. What types of connection are you most interested in?

Connect to Catheter Access Buttons. Connect to a harness or a jacket. Connect directly to an externalized catheter.

> Integrating Catheter Access Buttons with Culex

6. A unique feature of the Raturn is the ability to collect other streams of data, including urine and feces from rats. What other biofluids or data would you like to collect using the Culex® with Raturn or Pigturn, aside from blood?

Bile Urine and/or feces Animal Activity Data Microdialysates or Open Flow Microperfusion(direct tissue sampling) Wired EEG/EKG/ECG/EMG Wireless EEG/EKG/ECG/EMG (such as telemetry implants) Wired or wireless biosensors

7. Taking a completely hands-off approach to running pharmacology studies can save time, reduce animal stress, and improve data accuracy. This is true for both sampling and dosing. The Empis Automated Dosing system is a software-controlled pump that integrates with the Culex® Automated Sampling system. This is most useful for infusion studies, multi-drug studies or studies that require low-stress animals.

I would like to incorporate automated infusion into my Culex® system. I will dose through an implanted catheter using a separate pump or syringe. I will dose manually using a restraint method and needle (gavage, peritoneal, tail vein administration)

> Impact of dosing method to PK whitepaper

8. What route(s) of administration do you use for compound dosing? (Select all that apply)

If other, what route?

9. BASi provides training so that you can get the best start with your new equipment. This can include surgical training if you would like to perform your own implants, or it can focus on just the instrument.

I am interested in surgical training I am interested in equipment training I am interested in both training options I do not need training at this time. (You can always reach out to us if you change your mind)

10. We offer several ways to protect your equipment and protect yourself from lost time, including extended warranties, preventative maintenance visits or a full insurance plan. Let us know if you want to learn more about any of these options.

Yes, please send me additional details. No, I do not need additional information and will simply take advantage of BASi’s Repair Services.